Table 4 Association of phenotypic changes on T cells with clinical outcome (Relapse vs. NED) (Table 4a) and irAE (Yes vs. No) (Table 4b) was based on univariable logistic regression modeling
From: Biomarkers on melanoma patient T Cells associated with ipilimumab treatment
Biomarker | n | Slope | p-value | ½ IQR | OR (95% CI) |
|---|---|---|---|---|---|
a. Association of changes in biomarkers at 6 months with outcome (Relapse vs. NED) | |||||
%-Ki67 + EOMES + CD4+ | 19 | −3.5232 | 0.0285 | 0.5 | 0.17 ( 0.04, 0.83) |
%-CCR7 + CD8+ | 37 | −0.0947 | 0.0379 | 7.4 | 0.50 ( 0.26 0.96) |
%-EOMES + CD8+ | 36 | 0.1758 | 0.0072 | 5.5 | 2.63 ( 1.30, 5.32) |
% EOMES + GranzymeB + CD8+ | 19 | 0.2774 | 0.0293 | 5.8 | 5.00 ( 1.18, 21.23) |
b. Association of changes in biomarkers at 6 months with irAE (Yes vs. No) | |||||
%-Ki67 + CD8+ | 36 | −0.3167 | 0.0217 | 2.4 | 0.47 ( 0.24, 0.89) |