Skip to main content

Table 2 Univariate and Multivariate analyses of overall and disease-free survival for 161 HCC patients

From: High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

Variables Univariate analysis Multivariate analysis
Chi-Square (χ2) P value HR (95% CI) P value
Overall survival     
Age(≤55y vs >55y) 0.453 0.501   
Gender(male vs female) 1.875 0.171   
HBV infection(absent vs present) 0.011 0.915   
AFP level(≤400 ng/ml vs >400 ng/ml) 0.170 0.680   
Liver cirrhosis(absent vs present) 1.631 0.202   
Child-pugh(A vs B) 0.158 0.691   
Tumor size(≤5 cm vs >5 cm) 7.962 0.005 1.902(1.209-2.992) 0.005
Tumor number(single vs multipule) 8.763 0.003 0.601(0.240-1.504) 0.277
Tumor encapsulation(complete vs incomplete) 2.590 0.108   
TNM stage(I-II vs III) 8.484 0.004 1.567(0.771-3.184) 0.215
Tumor differentiation(I-II vs III-IV) 0.033 0.856   
HMGB1(low vs high) 7.022 0.008 1.834(1.167-2.881) 0.009
Disease-free survival     
Age(≤55y vs >55y) 0.812 0.367   
Gender(male vs female) 0.120 0.729   
HBV infection (absent vs present) 0.118 0.731   
AFP level(≤400 ng/ml vs >400 ng/ml) 0.748 0.387   
Liver cirrhosis(absent vs present) 1.972 0.160   
Child-pugh(A vs B) 1.502 0.220   
Tumor size(≤5 cm vs >5 cm) 8.367 0.004 1.661(1.119-2.465) 0.012
Tumor number(single vs multipule) 14.484 <0.001 0.484(0.218-1.071) 0.073
Tumor encapsulation(complete vs incomplete) 6.531 0.011 0.739(0.497-1.099) 0.136
TNM stage(I-II vs III) 11.494 0.001 1.314(0.719-2.402) 0.374
Tumor differentiation(I-II vs III-IV) 3.062 0.080 1.252(1.088-2.419) 0.291
HMGB1(low vs high) 8.176 0.004 1.622(1.088-2.419) 0.018
  1. HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1, HR: Hazard Ratio.