Table 2 Univariate and Multivariate analyses of overall and disease-free survival for 161 HCC patients
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Chi-Square (χ2) | P value | HR (95% CI) | P value | |
Overall survival | ||||
Age(≤55y vs >55y) | 0.453 | 0.501 | ||
Gender(male vs female) | 1.875 | 0.171 | ||
HBV infection(absent vs present) | 0.011 | 0.915 | ||
AFP level(≤400 ng/ml vs >400 ng/ml) | 0.170 | 0.680 | ||
Liver cirrhosis(absent vs present) | 1.631 | 0.202 | ||
Child-pugh(A vs B) | 0.158 | 0.691 | ||
Tumor size(≤5 cm vs >5 cm) | 7.962 | 0.005 | 1.902(1.209-2.992) | 0.005 |
Tumor number(single vs multipule) | 8.763 | 0.003 | 0.601(0.240-1.504) | 0.277 |
Tumor encapsulation(complete vs incomplete) | 2.590 | 0.108 | ||
TNM stage(I-II vs III) | 8.484 | 0.004 | 1.567(0.771-3.184) | 0.215 |
Tumor differentiation(I-II vs III-IV) | 0.033 | 0.856 | ||
HMGB1(low vs high) | 7.022 | 0.008 | 1.834(1.167-2.881) | 0.009 |
Disease-free survival | ||||
Age(≤55y vs >55y) | 0.812 | 0.367 | ||
Gender(male vs female) | 0.120 | 0.729 | ||
HBV infection (absent vs present) | 0.118 | 0.731 | ||
AFP level(≤400 ng/ml vs >400 ng/ml) | 0.748 | 0.387 | ||
Liver cirrhosis(absent vs present) | 1.972 | 0.160 | ||
Child-pugh(A vs B) | 1.502 | 0.220 | ||
Tumor size(≤5 cm vs >5 cm) | 8.367 | 0.004 | 1.661(1.119-2.465) | 0.012 |
Tumor number(single vs multipule) | 14.484 | <0.001 | 0.484(0.218-1.071) | 0.073 |
Tumor encapsulation(complete vs incomplete) | 6.531 | 0.011 | 0.739(0.497-1.099) | 0.136 |
TNM stage(I-II vs III) | 11.494 | 0.001 | 1.314(0.719-2.402) | 0.374 |
Tumor differentiation(I-II vs III-IV) | 3.062 | 0.080 | 1.252(1.088-2.419) | 0.291 |
HMGB1(low vs high) | 8.176 | 0.004 | 1.622(1.088-2.419) | 0.018 |