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Table 1 Correlations between HMGB1 expression and clinicopathalogic characteristics in 161 patients with HCC

From: High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

Variables All Patients (n = 161) High HMGB1 (n = 69) Low HMGB1 (n = 92) P value
Age(mean ± SD, year) 46.1 ± 11.5 44.9 ± 11.6 48.1 ± 11.3 0.511
 ≤55 128 59 69 0.103
 >55 33 10 23  
Gender 0.639
 Male 140 61 79  
 Female 21 8 13  
HBV infection 0.377
 Absent 17 9 8  
 Present 144 60 84  
AFP level 0.785
 ≤400 ng/ml 89 39 50  
 >400 ng/ml 72 30 42  
Liver cirrhosis  
 Absent 22 9 13  
 Present 139 60 79  
Child-pugh 0.403
 A 158 67 91  
 B 3 2 1  
Tumor size(mean ± SD, cm) 6.3 ± 4.1 6.0 ± 3.6 6.5 ± 4.5 0.075
 ≤5 cm 85 36 49 0.892
 >5 cm 76 33 43  
Tumor number     
 Single 147 62 85 0.575
 2-3 14 7 7  
Tumor encapsulation     0.035
 Complete 71 37 34  
 Incomplete 90 32 58  
TNM stage     0.036
 I 131 51 80  
 II-III 30 18 12  
Tumor differentiation     
 I-II 67 23 44 0.066
 III-IV 94 46 48  
  1. HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1.