High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy

Table 1 Correlations between HMGB1 expression and clinicopathalogic characteristics in 161 patients with HCC

Variables	All Patients (n = 161)	High HMGB1 (n = 69)	Low HMGB1 (n = 92)	P value
Age(mean ± SD, year)	46.1 ± 11.5	44.9 ± 11.6	48.1 ± 11.3	0.511
≤55	128	59	69	0.103
>55	33	10	23
Gender				0.639
Male	140	61	79
Female	21	8	13
HBV infection				0.377
Absent	17	9	8
Present	144	60	84
AFP level				0.785
≤400 ng/ml	89	39	50
>400 ng/ml	72	30	42
Liver cirrhosis
Absent	22	9	13
Present	139	60	79
Child-pugh				0.403
A	158	67	91
B	3	2	1
Tumor size(mean ± SD, cm)	6.3 ± 4.1	6.0 ± 3.6	6.5 ± 4.5	0.075
≤5 cm	85	36	49	0.892
>5 cm	76	33	43
Tumor number
Single	147	62	85	0.575
2-3	14	7	7
Tumor encapsulation				0.035
Complete	71	37	34
Incomplete	90	32	58
TNM stage				0.036
I	131	51	80
II-III	30	18	12
Tumor differentiation
I-II	67	23	44	0.066
III-IV	94	46	48

HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1.

ISSN: 1479-5876