Table 1 Baseline characteristics of severe sepsis patients and control subjects
Control n = 33 | Study Patients n = 67 | p value | |
|---|---|---|---|
Age (y) (mean±SD) | 66.3± 8.0 | 64.8± 13.8 | 0.57 |
Male (%) | 66.7 | 65.7 | 1.00 |
Underlying diseases | |||
Diabetes mellitus (%) | 54.5 | 35.8 | 0.09 |
Hypertension (%) | 60.6 | 44.8 | 0.20 |
Cardiac disease (%) | 12.1 | 11.9 | 1.00 |
Systolic blood pressure (mmHg) (mean±SD) | 143±15.2 | 112.2±42.3 | <0.001 |
Diastolic blood pressure (mmHg) (mean±SD) | 76.5±10.1 | 70.5±24.2 | 0.09 |
Laboratory data † | |||
Mean (SD) WBC (×10 9 /L) | 6.8 (2.5) | 15.9 (10.7) | <0.001 |
Mean (SD) Platelet (×10 4 /L) | 234.4 (66.4) | 158.2 (94.4) | <0.001 |
Mean (SD) Hemoglobin(mg/dL) | 13.6 (1.7) | 11.9 (2.2) | <0.001 |
Mean (SD) CRP (mg/dL) | 1.2 (0.9) | 189.6 (124.8) | <0.001 |
Median (IQR) plasma nuclear DNA (ng/mL) | 25 (19,41) | 436 (216,1140) | <0.001 |
Median(IQR) plasma mitochondrial DNA ( ng/mL) | 16 (7,23) | 149 (79,304) | <0.001 |