Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

Table 3 Oncogene mutations detected in tumorgrafts and originating patient tumors

Model	Tumor Type	Gene	Mutation	Primary Tumor Mutation Status	Tumorgraft Mutation Status
VARI-LTM-041	Colorectal Cancer	KRAS	G12V	TRUE	TRUE
VARI-LTM-041	Colorectal Cancer	PIK3CA	R88Q	TRUE	TRUE
VARI-LTM-041	Colorectal Cancer	PIK3CA	E545K	TRUE	TRUE
VARI-LTM-044	Cecal Adenocarcinoma	KRAS	G13D	TRUE	TRUE
VARI-LTM-026	Colorectal Cancer	KRAS	G12D	FALSE	TRUE
VARI-LTM-086	Melanoma	BRAF	V600E	TRUE	TRUE
VARI-LTM-027	Melanoma	NRAS	Q61R	TRUE	TRUE
VARI-LTM-034	Pancreatic Cancer	KRAS	Q61H	TRUE	TRUE

ISSN: 1479-5876