Enhanced antitumoral efficacy and immune response following conditionally replicative adenovirus containing constitutive HSF1 delivery to rodent tumors

Table 1 Number of animals resistant to tumor formation after treatment

	PBS	Adel55	Adel55-cHSF1	Adel55-HSF1i	Adel55-HSP70	Adel55-HSP90
B16	0/21	0/19	20/21*	0/21	12/21	11/21
CT26	0/22	0/17	24/25*	0/23	15/23	14/23

Mice with approximately 100 mm³ B16 or CT26 tumors growing subcutaneously were treated by intratumoral administration of 5 × 10⁸ pfu agents in the top column once a day for 2 consecutive days. Tumors were excised after 72 h and animals were re-inoculated with autologous tumor cells 2 weeks after surgery. Positive tumor formation was determined by at least minimal, palpable tumor 2 weeks from the time of tumor injection. Untreated animals as a positive control were injected and showed tumor formation. *represent statistical significance (P < 0.05, Adel55-cHSF1 vs. Adel55-HSP70 or Adel55-HSP90).

ISSN: 1479-5876