PAI-1 excess and decrease active MMPs impair monocyte migration in diabetes
Melvin Hayden, Department of Family and Community Medicine University of Missouri School of Medicine
10 December 2003
Congratulations on an excellent article.
In additon to increased bFGF and VEGF in diabetic peripheral monocytes, have you considered the elevation in PAI-1 levels as being implicated in the Vascular Paradox of diabetes: Accelerated angiogenesis and impaired arteriogenesis (collateral formation)?
Excess PAI-1 would result in a decrease in Plasmin, which converts latent MMPs to active MMPs.
If latent MMP activation is impaired then the extracellular matrix would not be digested and thus impair the migration of the monocyte within the extracellular matrix [1].
1. Hayden MR, Tyagi SC: Arteriogenesis: Angiogenesis within Unstable Atherosclerotic Plaque-- Interactions with Extracellular Matrix.
Curr Interv Cardiol Rep. 2000 Aug;2(3):218-227
Thank you for your excellent article and I would appreciate any comments you might have regarding this issue as it seems to relate to your excellent publication.
PAI-1 excess and decrease active MMPs impair monocyte migration in diabetes
10 December 2003
Congratulations on an excellent article.
In additon to increased bFGF and VEGF in diabetic peripheral monocytes, have you considered the elevation in PAI-1 levels as being implicated in the Vascular Paradox of diabetes: Accelerated angiogenesis and impaired arteriogenesis (collateral formation)?
Excess PAI-1 would result in a decrease in Plasmin, which converts latent MMPs to active MMPs.
If latent MMP activation is impaired then the extracellular matrix would not be digested and thus impair the migration of the monocyte within the extracellular matrix [1].
1. Hayden MR, Tyagi SC: Arteriogenesis: Angiogenesis within Unstable Atherosclerotic Plaque-- Interactions with Extracellular Matrix.
Curr Interv Cardiol Rep. 2000 Aug;2(3):218-227
Thank you for your excellent article and I would appreciate any comments you might have regarding this issue as it seems to relate to your excellent publication.
Sincerely,
M.R. (Pete) Hayden, M.D.
Adjunct Assistant Professor
Department of Family and Community Medicine
University of Missouri School of Medicne
Competing interests
NONE