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Table 2 Effect of NG-methyl-L-arginine on inhibition of arginase activity by rIFN-γ

From: rIFN-γ-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition

Cell line Arginase activity (μg urea/mg protein)
  Control NMMA (1 mM) rIFN-γ (500 U/ml) rIFN-γ + NMMA
2774 1.8 1.7 1.0 0.7
CAOV3 2.1 1.5 0.8 0.6
NMP-1 0.5 0.5 0.1 0.1
2008 1.2 1.3 2.1 2.4
2008.C13 1.6 1.6 2.6 3.4
  1. The cells were incubated with control medium, rIFN-γ, and/or NMMA for 72 hours and processed as described in Materials and Methods.