Fig. 2

Overexpression of CAV3 protected against cardiac dysfunction and cardiac remodeling in db/db mice. A Western blotting and associated quantitative analysis the CAV3 protein expression levels in the hearts of db/db mice with or without CAV3 overexpression in vivo (n = 7 mice). B–F The body weight, food intake and blood glucose levels of wt and db/db mice among each group were showed by a line chart (n = 7 mice). G Hemodynamic analysis (dp/dtmin) of wt mice and db/db mice with or without CAV3 overexpression. (n = 7 mice). H Representative images of echocardiograph (E/A) and relevant quantification analysis in wt mice and db/db mice with or without CAV3 overexpression (n = 7 mice). I The HW/TL ratio was quantitatively analyzed in wt mice and db/db mice with or without CAV3 overexpression (n = 7 mice). J Representative images of H&E staining and WGA staining to detect cardiomyocyte cross-sectional area, Sirius red staining to detect myocardial interstitial collagen and relevant quantification analysis in wt mice and db/db mice with or without CAV3 overexpression (n = 7 mice). Data are depicted as mean ± SD. *p < 0.05, **p < 0.01