Fig. 2
From: Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system
Representation of the human kallikrein-kinin system in plasma and tissue and identified drug targets. ACE: Angiotensin-converting enzyme, B1R: Bradykinin B1 receptor, B2R: Bradykinin B2 receptor, BK: Bradykinin, BK 1–8: Bradykinin 1–8, C1INH: C1 esterase inhibitor, ERT: Enzyme replacement therapy, F12: Coagulation factor XII gene, FXII: Coagulation factor XII, HK: High molecular weight kininogen, KLK1: Tissue kallikrein gene, KLKB1: Prekallikrein gene, LK: Low molecular weight kininogen, Lys-BK: Lysin-Bradykinin/Kallidin, Lys-BK 1–8: Lysin-Bradykinin 1–8/Kallidin 1–9, mRNA: Messenger ribonucleic acid, PK: Plasma prekallikrein, PKa: Plasma kallikrein, PRCP: Prolylcarboxypeptidase, PRT: Protein replacement therapy, SERPING1: C1 esterase inhibitor gene, TK: Tissue kallikrein. Created with BioRender.com