Fig. 4

Analysis of the 453 heteroplasmic variants called by Pime-Seq in the 192 prospective samples. A Overall distribution of the 453 heteroplasmic variants on the mitochondrial genome; B The distribution of the variants with low-level HF and high-level HF; C The ratio of variants with low-level HF to high-level HF in different mtDNA locations; D The ratio of synonymous variants to non-synonymous in variants with low-level HF and high-level HF