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Table 1 Baseline characteristics for males from UK biobank cancer follow-up cohort

From: An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study

Follow-up cohort

General-population

EO-population

LO-population

(N = 167,517)

(N = 28,725)

(N = 138,792)

Non incident

Incident PCa

Non incident

Incident PCa

Non incident

Incident PCa

N (%)

162,635 (97.09)

4882 (2.91)

28,520 (99.28)

205 (0.72)

134,115 (96.63)

4677 (3.37)

Age, Mean (SD)

56.83 (8.06)

62.37 (5.16)

44.07 (2.38)

49.05 (3.31)

59.54 (5.97)

62.95 (4.38)

Exit-age, Mean (SD)a

64.55 (8.03)

66.23 (5.32)

51.77 (2.30)

52.37 (2.64)

67.26 (5.91)

66.83 (4.53)

BMI, Mean (SD)

27.86 (4.25)

27.55 (3.83)

27.56 (4.29)

27.18 (3.53)

27.92 (4.23)

27.56 (3.84)

Smoking status, N (%)

 Never

79,849 (49.10)

2305 (47.21)

16,886 (59.21)

139 (67.80)

62,963 (46.95)

2166 (46.31)

 Ever

82,238 (50.56)

2557 (52.38)

11,587 (40.63)

66 (32.20)

70,651 (52.68)

2491 (53.26)

 Missing

548 (0.34)

20 (0.1)

47 (0.16)

0 (0.00)

501 (0.37)

20 (0.43)

Drinking status, N (%)

 Never

2698 (1.66)

78 (1.60)

410 (1.44)

4 (1.95)

2288 (1.71)

74 (1.58)

 Ever

159,791 (98.25)

4804 (98.40)

28,080 (98.46)

201 (98.05)

131,711 (98.21)

4603 (98.42)

 Missing

146 (0.09)

0 (0.00)

30 (0.11)

0 (0.00)

116 (0.09)

0 (0.00)

Family history of PCa, N (%)

 No

143,742 (88.38)

4034 (82.63)

25,548 (89.58)

153 (74.63)

118,194 (88.13)

3881 (82.98)

 Yes

12,095 (7.44)

628 (12.86)

1858 (6.51)

44 (21.46)

10,237 (7.63)

584 (12.49)

 Missing

6798 (4.18)

220 (4.51)

1114 (3.91)

8 (3.90)

5684 (4.24)

212 (4.53)

  1. General-population covered all participants; EO-cohort was consisted of individuals with exit-age ≤ 55 years old; LO-cohort comprised individuals with exit-age > 55 years old
  2. PCa prostate cancer, PRS polygenic risk score, SD standard deviation, IQR interquartile range
  3. aAge for diagnosis of PCa or censoring otherwise