Fig. 2

Risk estimates for PCa associated with a General-PRS (A–C), an EOPC-PRS (D–F) and an LOPC-PRS (G–I) in the General-, EO- and LO-population stratified by family history. Weighted Cox proportional hazard models were adjusted for age at assessment, BMI, smoking status, drinking status, assessment center and top 10 principal components. General-population covered all participants; EO-population was consisted of individuals with exit-age ≤ 55 years old; LO-population comprised individuals with exit-age > 55 years old. PCa prostate cancer, PRS polygenic risk score, HR hazard ratio, EOPC early-onset prostate cancer, LOPC late-onset prostate cancer, SD standard deviation