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Table 5 Association between FGFR4 p.G388R, TGRs, basal CEA, NLR and response to TAS-102

From: Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment

 

Disease Control

 

Characteristic

Yes (%)

No (%)

P

FGFR4 p.G388R

   

 No

8 (38.1)

24 (92.3)

 

 Yes

13 (61.9)

2 (7.7)

 < 0.0001

TGR

   

 Low

14 (66.6)

9 (34.6)

 

 High

7 (33.3)

17 (65.4)

0.0306

CEA

   

  < 200 ng/ml

13 (61.9)

10 (38.5)

 

  ≥ 200 ng/ml

8 (38.1)

16 (61.5)

0.1138

NLR

   

  < 5

12 (57.1)

10 (38.5)

 

  ≥ 5

9 (42.9)

16 (61.5)

0.2068

LDH

   

 Low

12 (57.1)

8 (30.8)

 

 High

9 (42.9)

18 (69.2)

0.0721

  1. CEA: CarcinoEmbryonic Antigen; DC: Disease Control; LDH: Lactic DeHydrogenase; NLR: Neutrophil to Lymphocyte Ratio; TGR: Tumour Growth Rate