Table 1 Colocalization results of QTLs for site with mental disorder
From: Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia
PPI | |||
|---|---|---|---|
Target | Mental disorders | eQTL-PP.H4 | pQTL- PP.H4 |
ITIH3 | Depression | Â | 0.999 |
ITIH4 | Depression | 0.069 | Â |
NT5C2 | Depression | 0.000 | Â |
ITSN1 | Schizophrenia | 0.003 | Â |
PSMA4 | Schizophrenia | 0.000 | Â |
Comorbidity sit | |||
|---|---|---|---|
Target | Â | depression-PP.H4 | schizophrenia-PP.H4 |
CYP21A2 | Depression/schizophrenia | 0.000 | 0.000 |
BTN3A1 | Depression/schizophrenia | 0.969 | 0.969 |
PSMB4 | Depression/schizophrenia | 1.000 | 1.000 |
TIMP4 | Depression/schizophrenia | 0.992 | 0.992 |
Three-step SMR analysis | |||
|---|---|---|---|
Target | Â | eQTL-PP.H4 | pQTL-PP.H4 |
CCS | Depression | 0.000 | 0.989 |
CTSS | Schizophrenia | 0.013 | 0.998 |
DNPH1 | Schizophrenia | 0.000 | 0.998 |