Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks

Table 4 Hazard ratio for incident POAG according to the presence of ocular risk factors (n = 73,548)

	No of events/total no. of participants	Incidence rate per 1000 person-year (95% CI)	Absolute risk (%)	Crude		Model 1		Model 2
	No of events/total no. of participants	Incidence rate per 1000 person-year (95% CI)	Absolute risk (%)	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
IOP
< 21 mmHg	794/65,781	1.09 (1.01–1.16)	1.21	Ref.		Ref.		Ref.
≥ 21 mmHg	462/5786	7.45 (6.78–8.16)	7.99	6.89 (6.14–7.72)	< 0.001	6.30 (5.61–7.07)	< 0.001	6.74 (5.89–7.71)	< 0.001
Myopia
Non to mild	1069/63,708	1.51 (1.42–1.61)	1.68	Ref.		Ref.		Ref.
Mod to high	1300/73,548	2.13 (1.86–2.42)	2.35	1.41 (1.22–1.62)	< 0.001	1.58 (1.37–1.82)	< 0.001	1.59 (1.36–1.88)	< 0.001
CH
> 10.1 mmHg	647/43,703	1.33 (1.23–1.44)	1.48	Ref.		Ref.		Ref.
≤ 10.1 mmHg	609/27,864	1.97 (1.82–2.14)	2.19	1.48 (1.33–1.65)	< 0.001	1.32 (1.18–1.48)	< 0.001	1.24 (1.09–1.42)	0.0009

POAG primary open angle glaucoma, CH corneal hysteresis, IOP intraocular pressure, HR hazard ratio, CI confidence interval
Model 1: Age + sex + genotyping array + first ten principal components of ancestry
Model 2: Model 1 + body mass index + smoking status + systolic blood pressure + diastolic blood pressure + LDL cholesterol + HbA1c + Hypertension + use of anti-glaucoma eyedrops

ISSN: 1479-5876