Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks

Table 3 Hazard ratio for incident POAG according to POAG genetic risk (n = 73,548)

	No of events/total no. of participants	Incidence rate per 1000 person-year (95% CI)	Absolute risk (%)	Crude		Model 1		Model 2
	No of events/total no. of participants	Incidence rate per 1000 person-year (95% CI)	Absolute risk (%)	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
POAG genetic risk
Low	123/14,571	0.76 (0.63–0.90)	0.84	Ref.		Ref.		Ref.
Intermediate	723/44,413	1.47 (1.36–1.58)	1.63	1.94 (1.60–2.34)	< 0.001	1.96 (1.62–2.37)	< 0.001	2.19 (1.74–2.77)	< 0.001
High	414/13,856	2.71 (2.46–2.98)	2.99	3.58 (2.93–4.38)	< 0.001	3.66 (2.99–4.47)	< 0.001	4.14 (3.25–5.29)	< 0.001
Very high	40/708	5.19 (3.71–7.06)	5.65	6.86 (4.80–9.80)	< 0.001	6.92 (4.84–9.89)	< 0.001	8.76 (5.87–13.08)	< 0.001
Per SD increase	1300/73,548	1.59 (1.51–1.68)	1.77	1.60 (1.52–1.69)	< 0.001	1.61 (1.52–1.70)	< 0.001	1.64 (1.54–1.75)	< 0.001

POAG primary open angle glaucoma, PRS polygenic risk score, HR hazard ratio, CI confidence interval, SD standard deviation
Model 1: Age + sex + genotyping array + first ten principal components of ancestry
Model 2: Model 1 + body mass index + smoking status + income status + systolic blood pressure + diastolic blood pressure + LDL cholesterol + HbA1c + Hypertension

ISSN: 1479-5876