Table 1 Summary of population characteristics across POAG genetic risk groups in UK Biobank data (n = 73,548)
POAG genetic risk group | Total | Low risk | Intermediate risk | High risk | Very high risk | P value |
|---|---|---|---|---|---|---|
(N = 73,548) | (N = 14,571) | (N = 44,413) | (N = 13,856) | (N = 708) | ||
Age (years) | 56.9 ± 7.8 | 57.1 ± 7.8 | 56.9 ± 7.8 | 56.9 ± 7.8 | 57.1 ± 7.9 | 0.191 |
Sex (%) | Â | Â | Â | Â | Â | 0.335 |
 Female | 39,342 (53.5) | 7796 (53.5) | 23,660 (53.3) | 7501 (54.1) | 385 (54.4) |  |
 Male | 34,206 (46.5) | 6775 (46.5) | 20,753 (46.7) | 6355 (45.9) | 323 (45.6) |  |
 Current smoker (%) | 6912 (9.4) | 1369 (9.4) | 4233 (9.5) | 1253 (9.0) | 57 (8.1) | 0.214 |
Alcohol consumption (%) | Â | Â | Â | Â | Â | 0.979 |
 Never | 12,674 (17.2) | 2503 (17.2) | 7678 (17.3) | 2372 (17.1) | 121 (17.1) |  |
 < 2 times per week | 27,062 (36.8) | 5310 (36.5) | 16,351 (36.8) | 5142 (37.1) | 259 (36.7) |  |
 < 3–4 times per week | 17,602 (23.9) | 3525 (24.2) | 10,622 (23.9) | 3279 (23.7) | 176 (24.9) |  |
 Daily | 16,168 (22.0) | 3222 (22.1) | 9742 (21.9) | 3054 (22.1) | 150 (21.2) |  |
 Townsend deprivation index | − 1.3 ± 2.8 | − 1.4 ± 2.8 | − 1.3 ± 2.8 | − 1.3 ± 2.8 | − 1.2 ± 2.8 | 0.461 |
Systemic parameters | Â | Â | Â | Â | Â | Â |
 Hypertension (%) | 20,208 (27.5) | 4040 (27.7) | 12,200 (27.5) | 3783 (27.3) | 185 (26.1) | 0.726 |
 Diabetes (%) | 14,201 (19.3) | 2879 (19.8) | 8616 (19.4) | 2593 (18.7) | 113 (16.0) | 0.016 |
 Dyslipidemia (%) | 3032 (4.4) | 615 (4.5) | 1805 (4.4) | 589 (4.6) | 23 (3.5) | 0.409 |
 Obesity (%) | 17,549 (23.9) | 3604 (24.8) | 10,620 (24.0) | 3163 (22.9) | 162 (22.9) | 0.002 |
 Systolic BP (mmHg) | 140.6 ± 19.5 | 140.8 ± 19.7 | 140.5 ± 19.5 | 140.4 ± 19.6 | 140.8 ± 19.0 | 0.349 |
 Diastolic BP (mmHg) | 82.0 ± 10.6 | 82.0 ± 10.6 | 82.0 ± 10.6 | 82.0 ± 10.5 | 82.2 ± 10.2 | 0.873 |
 HbA1c (%) | 5.4 ± 0.6 | 5.4 ± 0.6 | 5.4 ± 0.6 | 5.4 ± 0.6 | 5.4 ± 0.6 | 0.745 |
 LDL cholesterol (mg/dL) | 137.3 ± 33.4 | 137.4 ± 33.6 | 137.5 ± 33.4 | 136.8 ± 33.3 | 137.1 ± 32.4 | 0.217 |
 BMI (kg/m2) | 27.4 ± 4.7 | 27.4 ± 4.8 | 27.4 ± 4.7 | 27.2 ± 4.7 | 27.1 ± 4.6 | 0.001 |
Ocular parameters | Â | Â | Â | Â | Â | Â |
 Spherical power (D) | − 0.7 ± 2.8 | − 0.5 ± 2.8 | − 0.7 ± 2.8 | − 0.8 ± 2.9 | − 1.1 ± 3.0 |  < 0.001 |
 Cylinder power (D) | − 0.8 ± 3.0 | − 0.6 ± 2.9 | − 0.8 ± 3.0 | − 1.0 ± 2.8 | − 1.1 ± 3.4 | 0.095 |
 Spherical equivalent (D) | − 0.2 ± 2.8 | − 0.1 ± 2.7 | − 0.2 ± 2.8 | − 0.4 ± 2.8 | − 0.6 ± 2.9 |  < 0.001 |
 IOPg (mmHg) | 15.8 ± 3.9 | 15.1 ± 3.7 | 15.8 ± 3.9 | 16.6 ± 4.1 | 17.5 ± 4.5 |  < 0.001 |
 Corneal hysteresis (mmHg) | 10.7 ± 2.5 | 10.8 ± 2.3 | 10.7 ± 2.5 | 10.6 ± 2.6 | 10.3 ± 2.3 |  < 0.001 |