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Table 1 Baseline characteristics of the patients in the refractory and non-refractory groups

From: Enhanced predictive validity of integrative models for refractory hyperthyroidism considering baseline and early therapy characteristics: a prospective cohort study

Baseline characteristics

Refractory

(n = 172)

Non-refractory

(n = 174)

P value

Age, year

31 (26–42)

38 (28–47)

< 0.001

Female sex, n (%)

131 (76.2%)

135 (77.6%)

0.754

Current smoking, n (%)

22 (12.8%)

14 (8.05%)

0.148

GD family history, n (%)

18 (10.3%)

18 (10.5%)

0.971

GO, n (%)

56 (32.6%)

29 (16.7%)

< 0.001

Initial goiter size (cm3)

20.5 (15.1–29.4)

16.7 (11.0–23.3)

< 0.001

Initial fT3 (pmol/L)

27.6 (15.3–40.1)

22.5 (15.5–33.0)

0.008

Initial fT4 (pmol/L)

70.3 (44.3–100.0)

57.5 (41.9–90.4)

0.021

Initial TSH (mIU/L)

0.005 (0.005–0.005)

0.005 (0.005–0.005)

0.564

Initial TPOAb (IU/mL)

166.4 (22.9–352.4)

100.1 (18.6–289.2)

0.128

Initial TgAb (IU/mL)

199.1 (26.4–497.6)

232.4 (32.5–493.3)

0.767

Initial TRAb (IU/L)

15.1 (5.4–29.0)

7.5 (3.9–15.2)

< 0.001

  1. GO Graves’ orbitopathy, GD Graves’ disease, fT3 free triiodothyronine, fT4 free thyroxine, TSH thyroid stimulating hormone, TPOAb thyroid peroxidase autoantibody, TgAb thyroglobulin autoantibody, TRAb thyroid stimulating hormone receptor autoantibody