Fig. 2
From: HERVs may perform as the initial trigger for acquired aplastic anemia
Cell communication between HSPCs and T cells, and expression of HERVs and HLAs. A Strengths of signal receptors and transmitters in different pathways of T cells and HSPCs. The colored bar at the top represents the sum of the numerical columns displayed in the heat map (incoming signals). The colored bar on the right represents the sum of a row of values (outgoing signals). In the color bar, red (or blue) indicates an increase (or decrease) of signals in AA compared to HCs. B Communication probability between cell clusters. Important ligand-receptor pairs involved in key signaling pathways where CD8+ T cells act as signal senders. C Box plots showing the consistency of high HERV expression with the expression of HLA loci in the HSC/MPP and MEP cell clusters in AA. The red and blue boxes represent calculations for the HSC/MPP and MEP cell clusters, respectively. D Heatmap displaying the correlations between high expression HERVs and HLA loci in the HSC/MPP and MEP cell clusters in AA. Red and blue indicate high and low correlation coefficients, respectively. * P < 0.05, ** P < 0.01, *** P < 0.001. The red and blue boxes for HERVs represent the correlations for the HSC/MPP and MEP cell clusters, respectively