Fig. 7

Cell trajectory and GRNs analysis for macrophage revealing distinct polarization in human NTDs. A Cell trajectory of macrophage displayed by subtypes (left) and pseudotime (right), respectively. B Each subtype exhibited separately along the cell trajectory of macrophage. C Cells from different samples projected to the macrophage trajectory. D Visualization of genes related to macrophage polarization state using branch heatmap. E Display of the top 5 regulons of average activity for each subtype using heatmap. F GRNs of the top 5 regulons in M1, M2, M3, M4, M6, M7, and M9 showing the TFs and target genes