Fig. 2

Tumor Microenvironment (drawed by Figdraw). The tumor microenvironment (TME) is the surrounding microenvironment in which tumor cells exist, including the surrounding vasculature, extracellular matrix (ECM), fibroblasts, myeloid-derived inflammatory cells, immune cells, and a variety of cytokines and signaling molecules. Cytokine signaling molecules released by immune cells infiltrated in the TME are involved in mediating immune-suppressive and/or immune-responsive events. DC Dendritic cell, NK CELL Natural killer cell, MDSC Myeloid-derived suppressor cell, CAF Cancer-associated fibroblast, TAM Tumor-associated macrophage, IL Interleukin, TNF-α Tumor necrosis factor-α, CXCL Chemokine, VEGF Vascular endothelial growth factor, TGF-β Transforming growth factor-β, Arg-1 Arginine-1, iNOS Inducible nitric oxide synthase, ROS Reactive oxygen species