Fig. 2

EV miR-625-3p is highly associated with PASI and BSA, most accurately differentiates mild and moderate-to-severe psoriasis, is psoriasis-specific, and declines significantly when successfully treated. A and B Plasma miR-625-3p, miR-4488 and miR-342-3p level plotted against A PASI and B BSA. The significance of the correlation was tested using the Spearman's rank correlation test. C Receiver Operating Characteristic (ROC) curves and associated AUC value of each upregulated EV miRNAs. A higher area under the ROC curve (AUC) indicates superior model discrimination, ranging from 0 (none) to 1 (perfect). D Experimental scheme for analysis of EV miRNA level in BD patients and before-and-after treatment. E qRT-PCR results of plasma levels of miR-625-3p and miR-4488 according to disease activity of patients with BD. The difference between groups was assessed using ordinary one-way ANOVA. F Expression level of EV miRNAs from plasma of patients before (Pre) and after (Post) treatment. Paired t-test was used to compare the two groups. *P < 0.05