Fig. 1

Differentially expressed (DE) miRNAs in extracellular vesicles (EV miRNAs) identified from blood and skin of patients with severe and mild psoriasis. A Experimental scheme for acquisition and analysis of EV miRNA (Screening phase shown in blue arrows and validation phase shown in red arrows). B DE miRNAs on volcano plot (Selected EV miRNAs shown in bold). Blue and red colored dots indicate miRNAs with |log2 fold change|≥ 2 and P ≤ 0.05, and grey colored dots represent miRNAs with no significant changes. C and D qRT-PCR results of selected C downregulated and D upregulated miRNAs in the plasma of psoriasis patients. E qRT-PCR results of upregulated miRNAs in skin of psoriasis patients. For comparisons of differences between groups C-E, ordinary one-way ANOVA was used. (F) The skin miR-625-3p level plotted against PASI and BSA. EV miRNAs; miRNAs in extracellular vesicles. The significance of the correlation was assessed by the Spearman's rank correlation test. *P < 0.05 and **P < 0.01