Table 1 Area over the NGR_fit curves (AOC)
Area over the curve (AOC) defined by each NGR_fit plot | ||||||
|---|---|---|---|---|---|---|
Lorlatinib | Repotrectinib | Entrectinib | Ceritinib | Crizotinib | ||
2D | Wild type | 0.44 ± 0.04 | 0.34 ± 0.04 | 0.37 ± 0.06 | 0.31 ± 0.06 | 0.43 ± 0.06 |
G2032R | 0.44 ± 0.02 | 0.29 ± 0.04 | 0.15 ± 0.04 | 0.15 ± 0.01 | 0.15 ± 0.01 | |
L2026M | 0.38 ± 0.04 | 0.37 ± 0.03 | 0.35 ± 0.02 | 0.31 ± 0.02 | 0.31 ± 0.02 | |
S1986Y | 0.42 ± 0.02 | 0.34 ± 0.06 | 0.33 ± 0.07 | 0.26 ± 0.03 | 0.26 ± 0.03 | |
3D | Wild type | 0.63 ± 0.04 | 0.56 ± 0.04 | 0.52 ± 0.01 | 0.51 ± 0.01 | 0.45 ± 0.01 |
G2032R | 0.11 ± 0.1 | 0.08 ± 0.09 | 0.26 ± 0.06 | 0.18 ± 0.003 | 0.24 ± 0.06 | |
L2026M | 0.45 ± 0.04 | 0.25 ± 0.03 | 0.26 ± 0.02 | 0.43 ± 0.003 | 0.54 ± 0.03 | |
S1986Y | 0.56 ± 0.03 | 0.55 ± 0.04 | 0.51 ± 0.01 | 0.51 ± 0.02 | 0.44 ± 0.02 | |