Fig. 4

Anatomopathological analysis of the brain slices from AD patients showing several types of 2C5 staining. At the early stages of the disease, one can observe a punctiform labeling (indicated by black stars), due to the presence of Tau oligomers, which initially appeared at the level of the axonal extensions, then to the cell bodies of the affected neurons (A) in the entorhinal cortex, and (B) in the hippocampus. The fibrillar forms (black arrowhead) of the Tau protein were detected in the cell bodies of neurons affected at the more advanced stages. For the scale reference, the black line in the right lower corner represents 50 µm