Fig. 8

DSPE-PEG-CMP-miR302-EXO treatment significantly preserved cardiac function. A Echocardiographic images of mice with myocardial I/R injury after DSPE-PEG-CMP-miR302-EXO treatment showed improved cardiac function. B Increased EF, FS, LV Mass Index, LV VolD, LV VolS, and decreased LVAWd, LVAWs, LVIDd, LVIDs, LVPWd and LVPWs of mice with myocardial I/R injury were observed after DSPE-PEG-CMP-miR302-EXO treatment. EF ejection fraction, FS fractional shortening, LV Mass Index left ventricular mass index, LV VOLd LV volume in diastole, LV VOLs LV volume in systole, LVAWd LV anterior wall thickness at the ends of diastole, LVAWs LV anterior wall thickness at the ends of systole, LVIDd LV end-diastolic internal diameter, LVIDs LV end-systolic internal diameter, LVPWd LV posterior wall thickness at the ends of diastole, LVPWs LV posterior wall thickness at the ends of systole. ^▲▲p < 0.01 vs control; *p < 0.05, **p < 0.01 vs Model; ^##p < 0.01 vs DSPE-PEG-CMP-EXO; ^&&p < 0.01 vs miR302