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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Engineered bone marrow mesenchymal stem cell-derived exosomes loaded with miR302 through the cardiomyocyte specific peptide can reduce myocardial ischemia and reperfusion (I/R) injury

Fig. 6

DSPE-PEG-CMP-miR302-EXO treatment significantly inhibited inflammatory response and IR injury. A–D ELISA showed that DSPE-PEG-CMP-miR302-EXO decreased levels of cTnI, CKMB, TNF-α and IL-1β in cardiomyocytes. A cTnI: cardiac troponin I; B CKMB: creatine kinase MB; C TNF-α: tumor necrosis factor-alpha; D IL-1β: interleukin (IL)-1 beta (β). E, F The miR302 level in serum and heart was detected with qRT-PCR, wherein the level was higher in DSPE-PEG-CMP-miR302-EXO group. Relative values were presented as fold change over control. G HE staining image showed reduced heart necrosis in the myocardial I/R injury after DSPE-PEG-CMP-miR302-EXO treatment. Scale bar = 100 μm

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Journal of Translational Medicine

ISSN: 1479-5876

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