Fig. 2

Single-cell transcriptome resolves heterogeneity of Trm_gut_CD8 in distinct intestine organs. A UMAP plot showing single cells in distinct intestine organs, labeled by T cell subsets. B The point plot indicating differentiation genes of Trm_gut_CD8 in distinct intestine organs. Genes with log2Foldchange greater than 0.5 and p value adjust less than 0.001 were annotated as differential genes. C The bar plot indicates enriched signaling pathways of Trm_gut_CD8 in distinct intestine organs. D Network showing the PPI in Trm_gut_CD8 in distinct intestine organs identified by STRING. E Circle plots indicating the number of interactions and the interaction strength of cell types in the DUO. F The dendrogram plot of the co-expression network of Trm_gut_CD8 in distinct intestine organs. G The dot plot indicating the expression features of gene modules in Trm_gut_CD8 of distinct intestine organs. H Genes in each module are ranked by kME using the PlotKMEs function