Table 6 Predictive power of MSI PCR according to the dMMR phenotype
dMMR Phenotype | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | % Agreement | Kappa value |
|---|---|---|---|---|---|---|
Colorectal | ||||||
Classic | 62.7 | 98.5 | 88.7 | 93.1 | 92.6 | 0.693 |
Non-classic | 37.2 | 98.5 | 72.7 | 93.4 | 92.3 | 0.455 |
Unusual | 5.1 | 98.5 | 25.0 | 91.1 | 89.9 | 0.056 |
Non-colorectal | ||||||
Classic | 50.0 | 96.4 | 77.8 | 88.3 | 86.9 | 0.535 |
Non-classic | 25.0 | 96.4 | 42.9 | 92.2 | 99.3 | 0.262 |
Unusual | 10.0 | 96.4 | 20.0 | 92.2 | 89.2 | 0.082 |