Fig. 5

HFHS diet disturbs the ovarian metabolism of female mice revealed by metabolomics. A Principal components analysis (PCA) of metabolomics from control and HFHS mice ovaries (n = 4 for each group). B Volcano plot of differential metabolites identified in ovary metabolomics. Up-regulated metabolites are shown in red and down-regulated metabolites are shown in blue. C Pathway analysis overview of control and HFHS metabolomics. D Bar charts of metabolite set enrichment analysis of HFHS group compared to controls. E Displaying the differential metabolite network using debiased sparse partial correlation. The bubble size and color represents the significant magnitude of target metabolites enrichment