Fig. 2

HFHS diet leads to hyperglycemia and insulin resistance in female mice. A Blood glucose levels in control and HFHS mice after fasting for 6 h or 16 h (control, n = 8; HFHS, n = 7–10). B Serum insulin levels of control and HFHS mice after fasting for 6 h (n = 7). C HOMA-IR in control and HFHS mice after fasting for 6 h (n = 7). D, E GTT and the related AUC in control and HFHS mice (control, n = 8; HFHS, n = 10). F, G ITT and the related AUC in control and HFHS mice (control, n = 8; HFHS, n = 10). Data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001