Fig.1

Analysis results of scRNA-seq of human DKD. A UMAP feature plot revealing the different clusters of renal cells. B Renal cell clusters were identified by specific marker expression. C Expression of CD133 (PROM1) in cell clusters in the DKD and the control (CTRL) groups. D Bubble plots showing the expression of CD133 (PROM1) in the combined data of DKD and CTRL, and split data. E GO_BP enrichment analysis of top 200 positive coexpression genes of CD133 (PROM1) in PTC cluster in combined data. PTC proximal tubular cell, DTC distal tubular cell, CD-PC collecting duct-principal cell, DTC/CD distal tubule cell/collecting duct, CD-IC collecting duct-intercalated cell, ENDO endotheliocyte, PEC parietal epithelial cell, PODO podocyte, MES mesangial cell, LEUK leukocyte