Table 3 Expression of m6A modulators and their functions in osteosarcoma
From: Recent advances of m6A methylation in skeletal system disease
m6A regulators | Cells/animals | Samples | Expression of m6A regulators | Targets | Function | Reference |
|---|---|---|---|---|---|---|
METTL3 | MG-63 and U2OS cell lines | Human OS tissue | UP | MALAT1 | Promoted proliferation and migration | [159] |
SaOS-2, HOS cell lines | Human OS tissue | UP | CircRNF220 | Promoted proliferation and invasion | [160] | |
MG-63 and HOS cell lines | Human OS tissue | UP | ZBTB7C | Promoted proliferation and suppressed apoptosis | [161] | |
Saos2, SJSA1, MG63, HOS, and U2OS cell lines | Human OS tissue | UP | DANCR | Promoted proliferation, migration and invasion | [162] | |
Four-week-old nude mice | Human OS tissue | UP | ATG5 | Promoted glycolysis, autophagy and progression | [163] | |
SAOS2, MG63, U2OS cell lines | Human OS tissue | UP | COPS5 | Promoted migration and invasion | [164] | |
MG63, HOS, U2OS, SAOS2 cell lines | – | UP | DIRAS1 | Promoted proliferation and invasion, suppressed apoptosis | [165] | |
HOS, U2OS, SAOS2 cell lines | Human OS tissue | UP | HDAC5 | Promoted proliferation and metastasis | [166] | |
MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | UP | TRAF6 | Promoted metastasis | [167] | |
MG63, U2OS cell lines | Human OS tissue | UP | CircNRIP1 | Promoted proliferation, migration and suppressed apoptosis | [168] | |
MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | Down | TRIM7 | Promoted migration, invasion and chemoresistance | [169] | |
MG63, HOS, U2OS, SAOS2 cell lines | – | UP | ATAD2 | Promoted proliferation and invasion | [170] | |
MG63, 143B, U2OS, SAOS2 cell lines | Human OS tissue | UP | DRG1 | Promoted migration and suppressed apoptosis | [171] | |
MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | UP | LEF1 | Promoted proliferation, migration and invasion | [172] | |
METTL14 | MG63, HOS, U2OS, SJSA-1 cell lines | Human OS tissue | UP | MN1 | Tumor progression and chemotherapy resistance | [173] |
MG63, HOS, U2OS, SAOS2 cell lines | – | UP | DIRAS1 | Promoted proliferation, invasion and migration | [165] | |
MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | Down | TRIM7 | Promoted migration, invasion and chemoresistance | [169] | |
U2OS and 143B cell lines | – | Down | Caspase-3 | Promoted proliferation, migration, invasion | [174] | |
FTO | MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | Down | KLF3 | Promoted proliferation, invasion, suppressed apoptosis | [175] |
HEK293T, HOS, U2OS, SJSA-1 cell lines | Human OS tissue | Up | DACT1 | Promoted proliferation and metastasis | [176] | |
WTAP | HOS, U2OS cell lines | Human OS tissue | Up | ALB | Promoted migration, invasion and tumor growth | [177] |
SaOS2, U2OS, MG63, HOS, and 143B cell lines | Human OS tissue | Up | SNHG10 | Promoted proliferation, migration and suppressed apoptosis | [178] | |
MG63, SAOS2 cell lines | Human OS tissue | Up | FOXD2-AS1 | Promoted migration, invasion and tumor growth | [179] | |
MG63, HOS, U2OS, SAOS2 and 143B cell lines | Human OS tissue | Up | HMBOX1 | Promoted proliferation and metastasis | [180] | |
ALKBH5 | KHOS, U2OS cell lines | Human OS tissue | Down | STAT3 | Promoted proliferation and tumorigenicity | [181] |
143B, U2OS, and SAOS2 cell lines | – | Down | USP22, RNF40 | Promoted proliferation and progression | [182] | |
U2OS cell lines | – | Down | YAP/miR-181b-5p | Promoted growth, invasion and suppressed apoptosis | [183] | |
LM7, SAOS2, HOS, U2OS, MG63 and 143B cell lines | Human OS tissue | Down | PVT1 | Promoted proliferation and tumorigenesis | [184] | |
RBM15 | 143B, HOS, MG‐63, U20S SJSA1, SAOS2 cell lines | Human OS tissue | UP | Circ-CTNNB1 | Promoted glycolysis and OS progression | [185] |
HOS, MG63, MNNG, and 143B cell lines | – | UP | RRN3, DIDO1 | Promoted invasion, migration, and metastasis | [186] | |
KIAA1429 | A673 and SKNMC cell lines | – | UP | STAT3 | Promoted proliferation and tumorigenicity in ES | [187] |
MG63 and U2OS cell lines | – | UP | AK2/STAT3 | Promoted proliferation, migration, and invasion | [188] | |
YTHDF1 | MG63, U2OS, HOS, SAOS2 cell lines | Human OS tissue | UP | CNOT7 | Promoted proliferation, migration and invasion | [189] |
143B cell line | - | DOWN | AC004812.2 | Promoted growth, immune cell infiltration | [190] | |
YTHDF2 | MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | Down | KLF3 | Promoted proliferation and invasion, suppressed apoptosis | [175] |
MG63, HOS, U2OS, SAOS2 cell lines | Human OS tissue | DOWN | TRIM7 | Promoted migration and invasion | [169] | |
MG63, U2OS, and 143B cell lines | Human OS tissue | DOWN | miR-766 | Promoted growth and invasion | [191] | |
YTHDF3 | MG63, SAOS2 cell lines | – | UP | PGK1 | Promoted proliferation and aerobic glycolysis | [192] |
IGF2BP1 | MG-63 and HOS cell lines | – | UP | ERRα | Chemoresistance | [193] |
143B cell line | – | DOWN | AC004812.2 | growth, immune cell infiltration↑ | [190] | |
U2OS, HOS, SAOS2 cell lines | – | UP | MSC-Exo-150 | proliferation, migration, invasion↑ apoptosis↓ | [194] | |
– | Human OS tissue | UP | microRNA-150 | Promoted metastasis and recurrence, chemoresistance | [195] | |
U2OS, HOS, SAOS2 cell lines | Human OS tissue | Up | IGF2, GLI1, CD44 | Promoted cell survival and proliferation↑ | [196] | |
IGF2BP2 | MG63, HOS, U2OS, SJSA-1 cell lines | Human OS tissue | UP | MN1 | Promoted tumor progression and chemotherapy resistance | [173] |
MG63, U2OS, HOS, 143B, and SAOS2 cell lines | Human OS tissue | UP | HCG11 | Promoted cell proliferation, DNA replication↑ | [197] | |
SAOS2, MG63, HOS and U2OS cell lines | – | UP | DDX11-AS1 | Promoted proliferation, metastasis | [198] | |
ELAVL1 | MG63, 143B, U2OS, SAOS2 cell lines | Human OS tissue | UP | DRG1 | Promoted proliferation and invasion | [171] |