Table 2 Functions of m6A regulators in osteoporosis

METTL3

mouse bone marrow mononuclear

macrophages

OVX mouse model

Up

EGR1/METTL3/

CHI3L1

Promoted osteoclast differentiation and osteoporosis development

[121]

BALB/c mice BMSC

–

Up

MHL/METTL3

Enhanced osteoblastogenesis

[122]

adipose stem cells in OP rats

OVX mouse model

Down

–

Decreased osteogenic differentiation capacity

[123]

HUXMA -01 BMSCs

Female C57BL/6 J mice

Up

METTL3/ MIR99AHG/ miR-4660

enhanced the osteogenic differentiation

[124]

OP mouse BMSCs

OVX mouse model

Down

Wnt signaling pathway

Decreased osteogenic potential

[125]

Human OP

BMSCs

–

Down

MRTTL3/ LINC00657/

miR-144-3p/

BMPR1B

Promoted osteogenic differentiation

[126]

MC3T3-E1 cells, Balb/c mouse BMSCs

Diabetic bone loss rat model

Up

METTL3/

ASK1-p38

Activated osteoblast ferroptosis

[127]

Human BMSCs

OVX mouse model

Up

piRNA-36741/

METTL3/ BMP2

Promoted osteogenic differentiation

[128]

Human BMSCs

OVX mouse model

Down

METTL3/

pre-miR-320/

RUNX2

Inhibited osteogenic differentiation

[129]

Mouse

BMSCs

OVX mouse model

Down

METTL3/ PTH /Pth1r

Impaired bone formation, osteogenic differentiation potential and increased marrow adiposity

[130]

METTL14

Murine RAW264.7 and MC3T3-E1 cell lines

–

Up

METTL14/ NFATc1/

YTHDF1-2

Decreased bone resorption of osteoclasts

[131]

Human BMSCs

–

Up

METTL14 /

miR-873

Inhibited osteogenic proliferation and differentiation

[132]

Human BMSCs

OVX mouse model

Down

METTL14/ GPX4

Promoted osteoclastogenesis and bone resorption

[133]

Mouse

BMSCs

OVX mouse model

Down

METTL14/ SIRT1

Suppressed osteoblast differentiation and promoted osteoclast differentiation

[134]

Human BMSCs

OVX mouse model

Down

METTL14/TCF1/

RUNX2

Suppressed osteoblast differentiation and promoted osteoclast differentiation

[135]

Human BMSCs

OVX mouse model

Down

METTL14/

SMAD1/IGFBP1

Inhibited osteogenic differentiation

[136]

Human BMSCs

OVX mouse model

Down

METTL14/

IGF2BPs/Beclin-1

Inhibited osteogenic differentiation and promoted

osteoclast differentiation

[137]

Mouse ASCs

OVX mouse model

Down

METTL14/ Notch1

Inhibited osteogenic differentiation

[138]

Human BMSCs

OVX mouse model

Down

miR-103-3p/

METTL14

Inhibited osteoblast proliferation, differentiation, and matrix mineralization

[139]

WTAP

Human BMSCs

OVX mouse model

Down

WTAP/DGCR8

miR-29b-3p/

HDAC4

Inhibited osteogenic differentiation and promoted adipogenic differentiation

[140]

Human BMSCs

OVX mouse model

Down

WTAP/YTHDC1/miR-181a and miR-181c/SFRP1

Inhibited osteogenic differentiation and promoted adipogenic differentiation

[141]

FTO

Mouse RAW264.7 cells

diabetic mouse model

Down

FTO/ TLR4

Promoted osteoclast differentiation

[120]

Human BMSCs

–

Down

FTO/YTHDF1/

PPARG

Inhibited osteogenic differentiation

[142]

–

OVX mouse model

UP

FTO/ NF-κB/

NFATc1

Promoted bone resorption and osteoclastogenesis

[143]

Human BMSCs

OVX mouse model

Up

FTO/Runx2

Promotes osteoporosis,

inhibited osteogenic differentiation

[144]

Human BMSCs

OVX mouse model

Up

miR-22-3p/

FTO/MYC/PI3K/AKT

Promotes osteoporosis,

inhibited osteogenic differentiation

[145]

Mouse

BMSCs

–

Down

miR-149-3p/FTO

Inhibited the adipogenic differentiation

[146]

ALKBH1

Mouse

BMSCs

Alkbh1 knockout mice model

Down

ALKBH1/ optn

Reduced bone mass and increased marrow adiposity

[147]