Table 1 Role of m6A modulators in osteoarthritis
From: Recent advances of m6A methylation in skeletal system disease
m6A regulators | Cells | Animals | Expression | Targets | Biological function | Reference |
|---|---|---|---|---|---|---|
WTAP | Human articular chondrocyte | DMM mouse model | Up | WTAP/YTHDF2/ miR-92b-5p/TIMP4 | OA progression | [69] |
METTL3 | Human articular chondrocyte | – | Up | METTL3/NEK7 | Chondrocytes pyroptosis | [70] |
METTL3 | Human articular chondrocyte | ACL-T mouse model | Up | METTL3/IGF2BP2/ STAT1/ADAMTS12 | Cartilage damage | [71] |
METTL3 | Human primary chondrocyte | MIA mouse model | – | METTL3/IGFBP7-OT/ DNMT1/ DNMT3a-IGFBP7 | Chondrocytes apoptosis | [72] |
METTL3 | Human articular chondrocyte | DMM mouse model | – | RPL38/METTL3/ SOCS2/JAK2/STAT3 | Inflammatory response | [73] |
METTL3 | Human articular chondrocyte | DMM mouse model | – | miR-1208/METTL3/ NLRP3 | Enhanced proliferation and migration, inhibited apoptosis | [74] |
METTL3 | Human articular chondrocyte | DMM mouse model | Down | CREB/miR-373/ METTL3/TFEB | Autophagy | [75] |
METTL3 | Human articular chondrocyte | – | Up | METTL3/LINC00680/SIRT1 | OA progression | [76] |
METTL3 | Human endplate chondrocyte | Sprague Dawley rat | Up | METTL3/Sox9 | OA progression | [77] |
METTL3 | Human fibroblast-like synoviocytes | DMM mouse model | – | METTL3/YTHDF2/ ATG7/GATA4 | Autophagy | [78] |
METTL3 | ATDC5 cell | MIA mouse model | Down | METTL3/YTHDF1/ Bcl2 | Inhibited the apoptosis and autophagy | [79] |
FTO | Human articular chondrocyte | DMM mouse model | Down | FTO/miR-3591-5p/ PRKAA2 | Alleviated cartilage damage | [80] |
FTO | C28/I2 cell | MIA mouse model | Down | FTO/miR-515-5p/ TLR4/MyD88/NF-κB | Reduced apoptosis, inhibited inflammation | [81] |
FTO | Mouse chondrocyte | Sprague Dawley rat | Up | OANCT /FTO/ PIK3R5/PI3K/AKT/mTOR pathway | OA progression | [82] |
FTO | Human articular chondrocyte | MIA mouse model | Down | FTO/AC008/ miR-328-3p‒AQP1/ ANKH | OA progression | [83] |
ALKBH5 | Human articular chondrocyte | – | DOWN | ALKBH5/YTHDF2/ HS3ST3B1-IT1/ HS3ST3B1 | OA progression | [84] |
ALKBH5 | Human bone marrow MSCs | ACLT mouse model | DOWN | ALKBH5/IGF2BP1/ CYP1B1 mRNA | MSC senescence | [85] |
ALKBH5 | Human articular chondrocyte | DMM mouse model | UP | ALKBH5/ MiR-654-3p/ TNFRSF9/ NF-κB | OA progression | [86] |