Fig. 4

DNMT3L mediates the cell proliferation and invasion through CDO1. A CCK-8 assays for indicated cells. B Cell apoptosis was measured by Hoechst-PI staining assays for indicated cells. C Cell cycle analysis using PI staining in indicated cells. D Transwell invasion assays for indicated cells. Scale bars = 100 μm. E Wound-healing migration assays for indicated cells. Scale bars = 200 μm. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. NS: no significant