Fig. 6

ZIKV-LAV entry in human GBM cells is mediated by Axl and integrin α_vβ₅. Evaluation of the effect of siRNA-mediated knockdown of either Axl or integrin α_vβ₅ gene on A–B viral entry in DBTRG (A) and T98G (B) cells; C–D protein expression of Axl (C) and integrin α_vβ₅ (D) on the cell surface; and E–F intracellular viral replication in DBTRG (E) and T98G (F) cells. SCR, scrambled siRNA. Int.α_vβ₅, integrin α_vβ_5. Data are presented as mean ± SEM. Non-parametric Mann–Whitney test or Kruskal–Wallis test with Dunn’s post-hoc correction was used to compare groups. p-values are shown accordingly: *p < 0.05. **p < 0.005, ***p < 0.001