Fig. 5

Enrichment of IgG plasma cells and immunosuppression of B cells in obese CRC. A UMAP plots of the B/plasma subsets, colored by cell subsets. B Tissue prevalence of each B/plasma cell subset estimated by the Ro/e score, in which Ro/e denotes the ratio of observed to expected cell number. C Dot plots showing the expression of the chemokine receptors in IgG⁺plasma cells. The pct.exp reflects the percentage of cells expressing the gene at non-zero levels. The Average expression reflects the averaged log-normalized expression. D Dot plots showing the expression of the chemokine in all cell types. The pct.exp reflects the percentage of cells expressing the gene at non-zero levels. The Average expression reflects the averaged log-normalized expression. E Dot plots showing the comparison of communication probabilities from four endothelial cell subsets to three plasma cell subsets among different groups. F Violin plots showing the expression of CXCL12 in endothelial cell subsets, colored by groups. G Dot plots showing typically significantly enriched GO terms in memory B cells. H Violin plots showing the antigen presentation score in memory B cells. Comparisons were performed by unpaired two-tailed Student’s t-test. Significance levels are expressed as *P < 0.05, **P < 0.01 and ***P < 0.001