Fig. 1

| SAE1 is overexpressed in gastric cancer (GC) and is associated with poor prognosis in GC patients. A The transcription levels of SAE1 in different tumor types from TCGA data analyzed in TIMER database. B Normalized expression value of SAE1 (log 2 transformation and Z correction) in GC tissues and adjacent tissues from the TCGA database. C The graph summarized immunohistochemical (IHC) scores of SAE1 expression in 93 pairs of GC and adjacent tissues from tissue microarray. D Representative images of IHC staining for SAE1 in human GC tissue microarray with 93 tumor tissues and paired adjacent tissues. (Magnification 40 × , 100 × , and 200 × ; bars = 20 μm). E The survival plot shows the prognosis in 304 GC patients with high SAE1 expression and 327 gastric cancer patients with low SAE1 expression from Kaplan–Meier Plotter database. F The survival plot shows the prognosis in 65 gastric cancer patients with high SAE1 expression and 28 gastric cancer patients with low SAE1 expression from GC tissue microarray. G SAE1 expression in several GC cell lines was analyses by western blot. The data is representative of 3 independent experiments