Fig. 2

Identification of classical SE-associated genes with prognostic value. A Venn diagram showing overlap between super-enhancer-associated genes with characteristic features in U2-OS and SJSA-1 cell lines. Gene names are listed in right panel. B Graphical view of sample collection. C UMAP plot of all the single cells, with each color-coded for the 7 main cell types in OS lesions. D Violin plots showing the normalized expression levels of identified SE-associated genes across the different OS lesions in malignant cells. E X-tile plots of candidate SE-associated genes for overall survival and lung metastasis-free survival in 70 cases.