Fig. 1

Suppression of SEs induced prominent anti-osteosarcoma effects. A Distribution of putative targeting pathways of 150 examined drugs in the library. B Summary of top-15 ranked inhibitors and corresponding targets as represented in an ‘IC50 heatmap’ format. C Gene Set Enrichment analysis (GSEA) showing the super-enhancer-associated transcript signature enriched in THZ2/THZ531-treated cells versus DMSO-treated cells. D Enrichment p-values for selected Gene ontology (GO) functional categories of downregulated SE-associated genes in U2-OS and SJSA-1 cells following treatment with 100 nM THZ1 or 200 nM THZ531