Table 1 Clinical characteristics of heart failure patients
Cardiac tissue | Plasma | |||||
|---|---|---|---|---|---|---|
mRNA-Seq | ncRNA-Seq | Western Blot | ELISA | |||
HF (n = 26) | HF (n = 42) | HF (n = 26) | Acute HF (n = 48) | Chronic HF (n = 15) | P value | |
Age (years) | 53 ± 9 | 53 ± 10 | 50 ± 13 | 71 ± 14 | 57 ± 10 | < 0.001 |
Gender male (%) | 96 | 93 | 85 | 67 | 87 | 0.195 |
Non-ischemic dilated cardiomyopathy (%) | 50 | 48 | 50 | 46 | 40 | 0.772 |
Ischemic cardiomyopathy (%) | 50 | 52 | 50 | 54 | 60 | |
NYHA class | III–IV | III–IV | III–IV | I–IV | III–IV | 0.001 |
BMI (kg/m2) | 27 ± 5 | 26 ± 4 | 26 ± 5 | 30 ± 5 | 25 ± 5 | 0.002 |
Hemoglobin (mg/dL) | 14 ± 3 | 13 ± 2 | 14 ± 3 | 12 ± 2 | 14 ± 2 | 0.002 |
Hematocrit (%) | 40 ± 7 | 40 ± 6 | 40 ± 6 | 38 ± 6 | 43 ± 7 | 0.009 |
Total cholesterol (mg/dL) | 155 ± 39 | 161 ± 45 | 154 ± 52 | 129 ± 33 | 116 ± 29 | 0.207 |
Prior hypertension (%) | 25 | 32 | 36 | 82 | 67 | 0.283 |
Prior smoking (%) | 71 | 72 | 64 | 50 | 40 | 0.561 |
Diabetes mellitus (%) | 29 | 29 | 26 | 46 | 20 | 0.129 |
Hypercholesterolemia (%) | 13 | 19 | 22 | 60 | 53 | 0.765 |
LVEF (%) | 21 ± 8 | 21 ± 7 | 24 ± 8 | 30 ± 13 | 21 ± 10 | 0.035 |
LVESD (mm) | 66 ± 12 | 61 ± 12 | 61 ± 12 | 44 ± 13 | 59 ± 11 | 0.001 |
LVEDD (mm) | 74 ± 11 | 69 ± 12 | 69 ± 12 | 56 ± 10 | 68 ± 10 | < 0.001 |