Fig. 4

Relationship of cardiac FAP with pro- and antifibrotic microRNAs in HF. A miRNA expression levels of profibrotic microRNAs in control subjects (n = 8) and patients with heart failure (n = 42). B Correlation of FAP mRNA levels with miR-433-3p expression levels. C miRNA expression levels of antifibrotic microRNAs in control subjects (n = 8) and patients with heart failure (n = 42). D Correlations of FAP mRNA levels with miR-9-5p and miR-19a-3p expression levels. Bars represent mean ± SEM values. Figures reflect the relative expression (in arbitrary units) extracted from the ncRNA-seq analysis for both patients and controls to provide an idea of the average expression of each of the molecules A.u., arbitrary units. Correlations were determined using Spearman’s correlation coefficient. Control subjects (gray), HF patients (light blue). *p < 0.05, **p < 0.01, ***p < 0.001. HF heart failure, miRNA microRNA