Fig. 2

Relationship of cardiac FAP with genes associated with the cardiac extracellular matrix. A Relative mRNA expression levels of fibrillar collagens type I and type III. B Correlations of FAP mRNA levels with COL1A2 and COL3A1 mRNA levels. C Relative mRNA expression levels of nonfibrillar collagens type IV and type VIII. D Correlation of FAP mRNA levels with COL8A1 mRNA levels. E Relative mRNA expression levels of ECM constituents. F Correlations of FAP mRNA levels with MFAP5 and BGN mRNA levels. G Relative mRNA expression levels of LOXL1. H Correlation between LOXL1 mRNA levels and ELN mRNA levels. Bars represent mean ± SEM values. In sections A–F, 10 control subjects and 26 patients with heart failure were analyzed. Figures reflect the relative expression (in arbitrary units) extracted from the mRNA-seq analysis for both patients and controls to provide an idea of the average expression of each of the molecules. A.u., arbitrary units. Correlations were determined using Spearman’s correlation coefficient. Control subjects (gray), heart failure patients (light blue). *p < 0.05, **p < 0.01, ***p < 0.001. BGN biglycan; COL1A1(1A2, 3A1, 4A1, 4A5, 8A1)- collagen type I (III, IV, VIII) α-1, α-2, α-5; ECM extracellular matrix, ELN elastin, FAP fibroblast activation protein, LOXL1 lysyl oxidase like 1, MFAP5 microfibril associated protein 5, MMP2 matrix metallopeptidase 2