Table 1 Baseline characteristics of 40,813 participants
Characteristics | Total | CumMHR < 0.234 & CumCRP < 1 mg/L | CumMHR < 0.234 & 1 ≤ CumCRP < 3 mg/L | CumMHR < 0.234 & CumCRP ≥ 3 mg/L | CumMHR ≥ 0.234 & CumCRP < 1 mg/L | CumMHR ≥ 0.234 & 1 ≤ CumCRP < 3 mg/L | CumMHR ≥ 0.234 & CumCRP ≥ 3 mg/L | P value |
|---|---|---|---|---|---|---|---|---|
Participants | 40813 | 7743 | 8564 | 4099 | 5177 | 8848 | 6382 | < 0.0001 |
Event-free time | 8.0 (5.7–8.9) | 8.2 (6.4–9.0) | 7.9 (5.8–9.0) | 8.0 (5.6–8.9) | 8.0 (5.8–8.7) | 7.9 (5.4–8.8) | 7.8 (5.1–8.8) | < 0.0001 |
Cumulative characteristics | ||||||||
CumMHR | 0.2 (0.2–0.3) | 0.2 (0.1–0.2) | 0.2 (0.1–0.2) | 0.2 (0.2–0.2) | 0.3 (0.3–0.4) | 0.3 (0.3–0.4) | 0.3 (0.3–0.4) | < 0.0001 |
CumHDL, mmol/L | 1.5 (1.3–1.8) | 1.7 (1.4–1.9) | 1.6 (1.4–1.9) | 1.7 (1.4–1.9) | 1.5 (1.3–1.6) | 1.5 (1.3–1.6) | 1.5 (1.3–1.7) | < 0.0001 |
CumMON, 109/L | 0.3 (0.3–0.4) | 0.3 (0.2–0.3) | 0.3 (0.2–0.3) | 0.3 (0.2–0.3) | 0.4 (0.4–0.5) | 0.4 (0.4–0.5) | 0.4 (0.4–0.5) | < 0.0001 |
CumCRP, mg/L | 1.6 (0.8–3.1) | 0.6 (0.4–0.8) | 1.7 (1.3–2.2) | 4.8 (3.7–6.7) | 0.7 (0.5–0.8) | 1.7 (1.3–2.2) | 5.2 (3.9–7.7) | < 0.0001 |
Baseline characteristics | ||||||||
Male, n (%) | 30634 (75.1) | 5138 (66.4) | 5891 (68.8) | 2660 (64.9) | 4332 (83.7) | 7482 (84.6) | 5131 (80.4) | < 0.0001 |
Age, years | 52.2 ± 11.8 | 51.2 ± 11.8 | 53.4 ± 11.8 | 56.7 ± 11.7 | 48.6 ± 10.5 | 50.6 ± 11.5 | 54.3 ± 12.0 | < 0.0001 |
BMI, kg/m2 | 25.0 ± 3.3 | 23.7 ± 3.0 | 24.9 ± 3.2 | 25.3 ± 3.5 | 24.5 ± 3.0 | 25.5 ± 3.2 | 26.1 ± 3.6 | < 0.0001 |
SBP, mmHg | 129.6 ± 18.6 | 125.6 ± 18.2 | 130.1 ± 18.5 | 132.2 ± 19.4 | 127.0 ± 16.9 | 130.7 ± 18.3 | 133.0 ± 19.1 | < 0.0001 |
DBP, mmHg | 80.7 (79.3–90.0) | 80.0 (74.0–90.0) | 80.7 (80.0–90.0) | 80.7 (80.0–90.0) | 80.7 (79.0–90.0) | 83.0 (80.0–90.0) | 83.3 (80.0–90.0) | < 0.0001 |
FBG, mmol/L | 5.2 ± 0.6 | 5.2 ± 0.6 | 5.3 ± 0.6 | 5.2 ± 0.6 | 5.2 ± 0.6 | 5.3 ± 0.6 | 5.2 ± 0.6 | < 0.0001 |
HDL-C, mmol/L | 1.5 (1.2–1.8) | 1.7 (1.4–2.0) | 1.7 (1.4–2.0) | 1.6 (1.4–1.9) | 1.4 (1.2–1.6) | 1.4 (1.2–1.6) | 1.3 (1.1–1.6) | < 0.0001 |
LDL-C, mmol/L | 2.6 ± 0.8 | 2.6 ± 0.7 | 2.8 ± 0.7 | 2.3 ± 1.0 | 2.6 ± 0.7 | 2.7 ± 0.7 | 2.4 ± 0.9 | < 0.0001 |
TC, mmol/L | 5.0 ± 1.0 | 5.0 ± 1.0 | 5.1 ± 1.0 | 5.2 ± 1.0 | 4.8 ± 0.8 | 4.8 ± 0.9 | 4.9 ± 1.0 | < 0.0001 |
TG, mmol/L | 1.3 (0.9–1.8) | 1.1 (0.8–1.5) | 1.2 (0.9–1.8) | 1.2 (0.9–1.8) | 1.2 (0.9–1.8) | 1.4 (1.0–2.1) | 1.4 (1.0–2.2) | < 0.0001 |
HsCRP, mg/L | 1.0 (0.5–2.4) | 0.5 (0.3–0.9) | 1.2 (0.7–2.1) | 2.8 (1.0–5.8) | 0.5 (0.1–0.9) | 1.3 (0.6–2.4) | 3.3 (1.3–6.6) | < 0.0001 |
Leukocytes, 109/L | 6.1 (5.2–7.2) | 5.5 (4.7–6.4) | 5.7 (4.8–6.6) | 5.7 (4.8–6.7) | 6.5 (5.6–7.5) | 6.7 (5.8–7.9) | 6.9 (5.9–8.0) | < 0.0001 |
Alcohol consumption, n (%) | < 0.0001 | |||||||
No | 26752 (65.5) | 5025 (64.9) | 5624 (65.7) | 3020 (73.7) | 3110 (60.1) | 5546 (62.7) | 4427 (69.4) | |
Yes | 14061 (34.5) | 2718 (35.1) | 2940 (34.3) | 1079 (26.3) | 2067 (39.9) | 3302 (37.3) | 1955 (30.6) | |
Smoking, n (%) | < 0.0001 | |||||||
Never smoker | 25248 (61.9) | 5160 (66.6) | 5609 (65.5) | 2913 (71.1) | 2895 (55.9) | 4881 (55.2) | 3790 (59.4) | |
Ever smoker | 1796 (4.4) | 320 (4.1) | 355 (4.1) | 176 (4.3) | 223 (4.3) | 422 (4.8) | 300 (4.7) | |
Current smoker | 13769 (33.7) | 2263 (29.2) | 2600 (30.4) | 1010 (24.6) | 2059 (39.8) | 3545 (40.1) | 2292 (35.9) | |
Family history of diabetes | 2162 (5.3) | 419 (5.4) | 454 (5.3) | 179 (4.4) | 306 (5.9) | 468 (5.3) | 336 (5.3) | 0.0481 |
Education, n (%) | < 0.0001 | |||||||
Less than high school | 31,295 (76.7) | 5504 (71.1) | 6342 (74.1) | 3256 (79.4) | 3961 (76.5) | 6953 (78.6) | 5279 (82.7) | |
High school and above | 9518 (23.3) | 2239 (28.9) | 2222 (25.9) | 843 (20.6) | 1216 (23.5) | 1895 (21.4) | 1103 (17.3) | |
Physical activities, n (%) | < 0.0001 | |||||||
Never | 13749 (33.7) | 2960 (38.2) | 2990 (34.9) | 1464 (35.7) | 1705 (32.9) | 2604 (29.5) | 2026 (31.7) | |
Occasionally | 21,329 (52.3) | 3547 (45.8) | 4101 (47.9) | 2061 (50.3) | 2848 (55.0) | 5134 (58.0) | 3638 (57.0) | |
Frequently | 5735 (14.1) | 1236 (16.0) | 1473 (17.2) | 574 (14.0) | 624 (12.1) | 1110 (12.5) | 718 (11.3) | |
Hypertension, n (%) | 19733 (48.3) | 2942 (38.0) | 4111 (48.0) | 2192 (53.5) | 2226 (43.0) | 4565 (51.6) | 3705 (58.1) | < 0.0001 |
Dyslipidemia, n (%) | 11100 (27.2) | 1556 (20.1) | 2186 (25.5) | 1085 (26.5) | 1317 (25.4) | 2726 (30.8) | 2224 (34.8) | < 0.0001 |
CVD, n (%) | 2236 (5.48%) | 297 (3.84%) | 459 (5.36%) | 291 (7.10%) | 187 (3.61%) | 506 (5.72%) | 496 (7.77%) | < 0.0001 |
Antihypertensives, n (%) | 2201 (5.4) | 315 (4.1) | 519 (6.1) | 310 (7.6) | 153 (3.0) | 398 (4.5) | 506 (7.9) | < 0.0001 |
Statin, n (%) | 230 (0.6) | 40 (0.5) | 52 (0.6) | 26 (0.6) | 17 (0.3) | 39 (0.4) | 56 (0.9) | 0.0014 |
Fibrate, n (%) | 65 (0.2) | 5 (0.1) | 9 (0.1) | 11 (0.3) | 2 (0.0) | 15 (0.2) | 23 (0.4) | < 0.0001 |