Exploring the role of ubiquitin regulatory X domain family proteins in cancers: bioinformatics insights, mechanisms, and implications for therapy

Table 2 Preclinical in vivo evidence of UBXDF effect on cancers

protein	Cancer type	Samples	Effects	References
UBXN10	Colon adenocarcinoma	Xenograft mouse model	Inhibits tumour growth	[66]
UBXN2A	Colorectal cancer	Xenograft mouse model	Inhibits proliferation and migration	[67]
UBXN2A	Colorectal cancer	Xenograft mouse model	Inhibits tumour growth	[68]
UBXN2A	Colorectal cancer	Xenograft mouse model	Inhibits tumour growth	[69]
FAF1	Breast cancer	Xenograft mouse model	Inhibits metastasis	[75]
FAF1	Non-small cell lung carcinomas	Xenograft mouse model	Reduces tumour volume and weight	[83]
FAF1	Malignant mesothelioma	Xenograft mouse model	Inhibits MM development	[91]
UBXN1	Diffuse gliomas	Xenograft mouse model	Inhibits tumour progression	[88]
UBXN1	Glioblastoma	Xenograft mouse model	Inhibits tumour growth and tumourigenesis	[87]
UBXN1	Colon adenocarcinoma	Xenograft mouse model	Inhibits tumour growth and tumourigenesis	[87]

ISSN: 1479-5876