Table 4 Overall MR analyses with strong genetic instruments (p < 5E−08) for causal effects of peripheral blood hematological traits and count data of immune-related cells on five types of ADs
Exposure | Outcome | No. of clumped SNPsa | No. of SNPs in MRAb | MR p-valuec | MR methodd | Heterogeneity | Pleiotropy | Directionality |
|---|---|---|---|---|---|---|---|---|
Immune-related cells | ||||||||
 CD4+ T | BAD | 1 | 1 | 3.90E−04 | Wald ratio | – | – | True |
Asthma2020 | 1 | 1.73E−13 | Wald ratio | – | – | True | ||
PA | 1 | 2.74E−04 | Wald ratio | – | – | True | ||
SA | 1 | 2.85E−01 | Wald ratio | – | – | True | ||
 CD4+ T/CD8+ T | BAD | 21 | 20 | 9.69E−01 | IVW (random effects) | Yes | No | True |
Asthma2020 | 16 | 2.42E−02 | IVW (random effects) | Yes | No | True | ||
ADE2015 | 5 | 4.70E−02 | MR Egger | Yes | Yes | True | ||
PA | 16 | 1.46E−01 | IVW (random effects) | Yes | No | True | ||
SA | 16 | 7.79E−01 | IVW (random effects) | Yes | No | True | ||
 CD56+ NK | BAD | 1 | 1 | 5.49E−01 | Wald ratio | – | – | True |
Asthma2020 | 1 | 2.66E−01 | Wald ratio | – | – | True | ||
ADE2015 | 1 | 7.16E−01 | Wald ratio | – | – | True | ||
 CD8+ T | BAD | 5 | 5 | 3.01E−01 | IVW (random effects) | Yes | No | True |
Asthma2020 | 3 | 7.31E−01 | IVW(random effects) | Yes | No | True | ||
PA | 4 | 7.57E−01 | IVW (fixed effects) | No | No | True | ||
SA | 4 | 5.44E−01 | IVW (random effects) | Yes | No | True | ||
Hematological traits | ||||||||
 HT | BAD | 1 | 1 | 3.00E−01 | Wald ratio | – | – | True |
Asthma2020 | 1 | 3.58E−01 | Wald ratio | – | – | True | ||
ADE2015 | 1 | 3.83E−01 | Wald ratio | – | – | True | ||
 LYMPH | BAD | 1 | 1 | 5.50E−01 | Wald ratio | – | – | True |
Asthma2020 | 1 | 5.23E−14 | Wald ratio | – | – | True | ||
 MCH | BAD | 4 | 3 | 4.58E−01 | IVW (random effects) | Yes | No | True |
Asthma2020 | 3 | 4.02E−01 | IVW (fixed effects) | No | No | True | ||
ADE2015 | 3 | 4.74E−01 | IVW (fixed effects) | No | No | True | ||
PA | 1 | 6.01E−01 | Wald ratio | – | – | True | ||
SA | 1 | 7.82E−01 | Wald ratio | – | – | True | ||
 MCV | BAD | 5 | 5 | 1.88E−01 | IVW (fixed effects) | No | No | True |
Asthma2020 | 4 | 2.00E−01 | IVW (fixed effects) | No | No | True | ||
ADE2015 | 5 | 3.63E−01 | IVW (fixed effects) | No | No | True | ||
PA | 1 | 6.01E−01 | Wald ratio | – | – | True | ||
SA | 1 | 7.82E−01 | Wald ratio | – | – | True | ||
 MONO | BAD | 3 | 3 | 2.46E−03 | IVW (fixed effects) | No | No | True |
Asthma2020 | 3 | 3.23E−01 | IVW (fixed effects) | No | No | True | ||
ADE2015 | 3 | 8.52E−01 | IVW (fixed effects) | No | No | True | ||
 PLT | BAD | 1 | 1 | 8.80E−01 | Wald ratio | – | – | True |
Asthma2020 | 1 | 4.11E−01 | Wald ratio | – | – | True | ||
ADE2015 | 1 | 4.90E−01 | Wald ratio | – | – | True | ||
 RBC | BAD | 1 | 1 | 8.03E−01 | Wald ratio | – | – | True |
Asthma2020 | 1 | 5.24E−01 | Wald ratio | – | – | True | ||
ADE2015 | 1 | 9.20E−01 | Wald ratio | – | – | True | ||