Exposure | Outcome | No. of clumped SNPsa | No. of SNPs in MRAb | MR p-valuec | MR methodd | OR | 95% LCI | 95% UCI |
---|
Asthma2018 | A2 | 36 | 36 | 4.22E−03 | IVW (random effects) | 0.88 | 0.80 | 0.96 |
1.56E−08 | IVW (fixed effects) | 0.88 | 0.84 | 0.92 |
1.48E−09 | RAPS | 0.87 | 0.83 | 0.91 |
B2 | 36 | 5.61E−03 | IVW (random effects) | 0.92 | 0.87 | 0.98 |
6.44E−08 | IVW (fixed effects) | 0.92 | 0.89 | 0.95 |
8.38E−09 | RAPS | 0.92 | 0.89 | 0.94 |
C2 | 36 | 9.23E−02 | IVW (random effects) | 0.98 | 0.95 | 1.00 |
1.51E−03 | IVW (fixed effects) | 0.98 | 0.96 | 0.99 |
7.33E−04 | RAPS | 0.98 | 0.96 | 0.99 |
- RAPS Robust Adjusted Profile Score, OR odds ratio, 95% LCI 95% lower confidence interva, 95% UCI 95% upper confidence interval
- aNo. of clumped SNPs: number of independent genetic SNPs with a p-value < 5 × 10–8 after clumping
- bNo. of SNPs in MRA: number of independent genetic SNPs used in the MR analysis for each pair of exposure and outcome
- cMR p-value: p-value of the most suitable MR method
- dThe most suitable MR analysis used in MR analysis. Bold values indicate that the MR p-value is less than 0.05, while italic values indicate that the MR p-value is marginally significant