Table 1 Top 10 significant core targets ranked using CytoHubba
No | Name | Description | MCC Score | BottleNeck Score | DC | BC | CC |
|---|---|---|---|---|---|---|---|
Sirolimus | |||||||
 1 | TP53* | Tumor protein p53 | 9.22E + 13 | 50.00 | 146.00 | 972.93 | 178.00 |
 2 | IL6* | Interleukin 6 | 9.22E + 13 | 19.00 | 163.00 | 1,400.41 | 186.50 |
 3 | STAT3* | Signal transducer and activator of transcription 3 | 9.22E + 13 | 15.00 | 134.00 | 541.92 | 172.00 |
 3 | VCAM1 | Vascular cell adhesion molecule 1 | 9.22E + 13 | 15.00 | 87.00 | 194.11 | 148.33 |
 5 | IL1B | Interleukin 1 beta | 9.22E + 13 | 8.00 | 146.00 | 898.27 | 178.00 |
 6 | MAPK14 | Mitogen-activated protein kinase 14 | 9.22E + 13 | 6.00 | 93.00 | 214.59 | 151.50 |
 6 | ESR1 | Estrogen receptor 1 | 9.22E + 13 | 6.00 | 113.00 | 489.63 | 161.33 |
 6 | ALB* | Albumin | 9.22E + 13 | 6.00 | 161.00 | 1,908.35 | 185.50 |
 9 | AKT1 | AKT serine/threonine kinase 1 | 9.22E + 13 | 4.00 | 173.00 | 1,687.52 | 191.50 |
 9 | MMP2 | Matrix metallopeptidase 2 | 9.22E + 13 | 5.00 | 99.00 | 220.08 | 154.50 |
 9 | SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 9.22E + 13 | 5.00 | 134.00 | 766.75 | 172.00 |
Rosuvastatin | |||||||
 1 | ALB* | Albumin | 9.22E + 13 | 44.00 | 93.00 | 1,177.20 | 105.08 |
 2 | AKT1* | AKT serine/threonine kinase 1 | 9.22E + 13 | 11.00 | 89.00 | 878.05 | 103.08 |
 3 | TNF* | Tumor necrosis factor | 9.22E + 13 | 8.00 | 97.00 | 1,270.34 | 106.92 |
 4 | IL1B* | Interleukin 1 beta | 9.22E + 13 | 6.00 | 79.00 | 557.01 | 97.92 |
 5 | SELE | Selectin E | 1.82E + 13 | 5.00 | 36.00 | 94.79 | 76.83 |
 6 | CAT | Catalase | 9.22E + 13 | 4.00 | 48.00 | 194.11 | 82.58 |
 6 | PTGIS | Prostaglandin I2 synthase | 279 | 5.00 | 12.00 | 400.50 | 61.67 |
 8 | MDM2 | MDM2 proto-oncogene | 9.22E + 13 | 2.00 | 33.00 | 50.64 | 74.42 |
 8 | ESR1 | Estrogen receptor 1 | 9.22E + 13 | 3.00 | 57.00 | 260.82 | 86.92 |
 8 | CASP3* | Caspase 3 | 9.22E + 13 | 3.00 | 65.00 | 379.67 | 90.92 |
 8 | PECAM1 | Platelet and endothelial cell adhesion molecule 1 | 9.22E + 13 | 1.00 | 50.00 | 129.10 | 83.42 |
 8 | MMP9* | Matrix metallopeptidase 9 | 9.22E + 13 | 5.00 | 77.00 | 474.21 | 96.92 |
Sirolimus + Rosuvastatin | |||||||
 1 | ALB* | Albumin | 9.22E + 13 | 40.00 | 79.00 | 992.34 | 87.00 |
 2 | AKT1* | AKT serine/threonine kinase 1 | 9.22E + 13 | 11.00 | 75.00 | 629.42 | 85.00 |
 3 | TNF* | Tumor necrosis factor | 9.22E + 13 | 5.00 | 82.00 | 952.30 | 88.50 |
 3 | ESR1 | Estrogen receptor 1 | 9.22E + 13 | 5.00 | 49.00 | 194.33 | 71.83 |
 5 | MMP9* | Matrix metallopeptidase 9 | 9.22E + 13 | 3.00 | 66.00 | 404.38 | 80.50 |
 5 | IL1B | Interleukin 1 beta | 9.22E + 13 | 7.00 | 67.00 | 418.99 | 81.00 |
 7 | IGF1 | Insulin-like growth factor 1 | 9.22E + 13 | 3.00 | 54.00 | 190.52 | 74.50 |
 7 | CAT | Catalase | 9.22E + 13 | 3.00 | 38.00 | 110.59 | 66.50 |
 7 | CASP3* | Caspase 3 | 9.22E + 13 | 3.00 | 58.00 | 322.68 | 76.50 |
 10 | SRC* | SRC proto-oncogene, non-receptor tyrosine kinase | 9.22E + 13 | 2.00 | 57.00 | 227.32 | 76.00 |
 10 | PPARA | Peroxisome proliferator-activated receptor alpha | 2.99E + 12 | 1.00 | 31.00 | 85.01 | 63.00 |
 10 | HSP90AA1* | Heat shock protein 90 alpha family class A member 1 | 9.22E + 13 | 2.00 | 48.00 | 162.96 | 71.50 |
 10 | HMOX1 | Heme oxygenase 1 | 3.46E + 12 | 2.00 | 34.00 | 228.22 | 64.50 |
 10 | MDM2 | MDM2 proto-oncogene | 9.22E + 13 | 2.00 | 31.00 | 37.13 | 62.83 |
 10 | SERPINA1 | Serpin family A member 1 | 1,670,018 | 2.00 | 22.00 | 70.77 | 58.33 |
 10 | MMP2 | Matrix metallopeptidase 2 | 7.18E + 13 | 2.00 | 47.00 | 127.75 | 71.00 |